Proliferative Glomerulopathy with Unusual Subendothelial Deposits of Striated Structure in Multiple Myeloma

Korean Journal of Nephrology 2010;29(6):772-775.

Yun-Gyoo Lee, M.D.1, Dong-Yeop Shin, M.D.1, Hyun-Jung Lee, M.D.1, Se-Youn Choi, M.D.1, Jae-yoon Park, M.D.1, Shin-young Ahn, M.D.1, Hajung Lee, M.D.1, Yunjung Oh, M.D.1, Kyung-Chul Moon, M.D.2, Kook-Hwan Oh, M.D.1 and Inho Kim, M.D.1

Department of Internal Medicine1 and Pathology2 Seoul National University Hospital, Seoul, Korea

증례 : Proliferative Glomerulopathy with Unusual Subendothelial Deposits of Striated Structure in Multiple Myeloma

Department of Internal Medicine1 and Pathology2 Seoul National University Hospital, Seoul, Korea

Abstract

A 50-year-old woman was admitted for the evaluation of proteinuria and renal biopsy. On the basis of the serum monoclonal protein, marrow plasma cell dyscrasia and end organ damage (nephritic range proteinuria), multiple myeloma was diagnosed. A renal biopsy showed a membranoproliferative glomerulonephritis pattern of injury and unusual organized deposits of striated structure in the subendothelial space, which were identified as non-amyloid non-immunoglobulin-derived deposits. These deposits contained regularly stacked straight electron-dense bands, which have not been described in the setting of paraproteinemia and/or plasma cell dyscrasia.

Key Words: Membranoproliferative glomerulonephritis, Deposit, Striated, Monoclonal gammopathy